South Carolina won its second straight in Death Valley last year, but it's Clemson who owns the all-time series by a commanding margin. The Tigers have won eight of the past 10 meetings against the Gamecocks and haven't lost in Columbia since 2013. South Carolina is ranked No. 13 in the preseason top 25 polls.

Oddsmakers and bettors reveal their early prediction for LSU vs. Clemson in this Week 1 college football game.

College football Week 1 odds, picks, predictions, TV channel, streaming information for LSU Tigers at Clemson Tigers game on Saturday, Aug. 30, 2025.