According to ESPN's Adam Schefter, San Francisco 49ers tight end George Kittle is unlikely to play in today's matchup against the Seattle Seahawks. Kittle, who has been dealing with a hamstring injury ...

For the first time all season, there's a new No. 1 in our NFL power rankings after the Chiefs lost to the Bills. But how far does Kansas City fall?

The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to ...

The injury-prone San Francisco 49ers are monitoring yet another health issue, this one involving quarterback Brock Purdy's ...

Meanwhile, Harbaugh is in Los Angeles, coaching the Chargers to a 7-3 record, with quarterback Justin Herbert looking like a ...

Enduring unprecedented circumstances, RT Abraham Lucas and C Olu Oluwatimi were positive additions to the Seattle Seahawks' offensive line in Week 11.

The San Francisco 49ers sustained several injuries in their loss to the Seattle Seahawks on Sunday, including to quarterback ...

Brock Purdy is dealing with soreness in his right (throwing) shoulder, coach Kyle Shanahan said Monday, and is day to day.

Quarterback Brock Purdy is day-to-day with a sore right shoulder, and EDGE Nick Bosa will be evaluated throughout the week ...

Floyd split a sack with Nick Bosa on Seattle's first offensive series and added a solo sack on the Seahawks' final drive late in the fourth quarter. It was the first time this season that the veteran ...

San Francisco 49ers head coach Kyle Shanahan spoke to reporters during a Monday conference call, providing key injury updates the day after the team's ...

With injuries piling up after Week 11 of the NFL season, here are the players you should be monitoring heading into Week 12.